Recombinant人Lunatic Fringe protein (ab116899)

概述

  • 产品名称
    Recombinant人Lunatic Fringe protein
  • 蛋白长度
    Full length protein

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MTPGRCCLAADIQVETFIFTDGEDEALARHTGNVVITNCSAAHSRQALSC KMAVEYDRFIESGRKWFCHVDDDNYVNLRALLRLLASYPHTRDVYVGKPS LDRPIQAMERVSENKVRPVHFWFATGGAGFCISRGLALKMSPWASGGHFM NTAERIRLPDDCTIGYIVEALLGVPLIRSGLFHSHLENLQQVPTSELHEQ VTLSYGMFENKRNAVHVKGPFSVEADPSRFRSIHCHLYPDTPWCPRTAIF
    • 分子量
      53 kDa including tags
    • 氨基酸
      1 to 250

技术指标

Our Abpromise guarantee covers the use of ab116899 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • 3-N-acetylglucosaminyltransferase lunatic fringe
    • Beta-1
    • Beta-13-N-acetylglucosaminyltransferase lunatic fringe
    • lfng
    • LFNG_HUMAN
    • O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
    • SCDO3
    see all
  • 功能
    Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning.
  • 疾病相关
    Defects in LFNG are the cause of spondylocostal dysostosis type 3 (SCDO3) [MIM:609813]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
  • 序列相似性
    Belongs to the glycosyltransferase 31 family.
  • 翻译后修饰
    A soluble form may be derived from the membrane form by proteolytic processing.
  • 细胞定位
    Golgi apparatus membrane.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE showing ab116899 at approximately 53.24 kDa stained with Coomassie Blue.

文献

ab116899 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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