Recombinant人Lunatic Fringe protein (ab116899)

概述

  • 产品名称Recombinant人Lunatic Fringe protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ8NES3
    • 种属Human
    • 序列MTPGRCCLAADIQVETFIFTDGEDEALARHTGNVVITNCSAAHSRQALSC KMAVEYDRFIESGRKWFCHVDDDNYVNLRALLRLLASYPHTRDVYVGKPS LDRPIQAMERVSENKVRPVHFWFATGGAGFCISRGLALKMSPWASGGHFM NTAERIRLPDDCTIGYIVEALLGVPLIRSGLFHSHLENLQQVPTSELHEQ VTLSYGMFENKRNAVHVKGPFSVEADPSRFRSIHCHLYPDTPWCPRTAIF
    • 分子量53 kDa including tags
    • 氨基酸1 to 250

技术指标

Our Abpromise guarantee covers the use of ab116899 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • 3-N-acetylglucosaminyltransferase lunatic fringe
    • Beta-1
    • Beta-13-N-acetylglucosaminyltransferase lunatic fringe
    • lfng
    • LFNG_HUMAN
    • O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
    • SCDO3
    see all
  • 功能Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning.
  • 疾病相关Defects in LFNG are the cause of spondylocostal dysostosis type 3 (SCDO3) [MIM:609813]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
  • 序列相似性Belongs to the glycosyltransferase 31 family.
  • 翻译后修饰A soluble form may be derived from the membrane form by proteolytic processing.
  • 细胞定位Golgi apparatus membrane.
  • Information by UniProt

Recombinant Human Lunatic Fringe protein 图像

  • 12.5% SDS-PAGE showing ab116899 at approximately 53.24 kDa stained with Coomassie Blue.

Recombinant Human Lunatic Fringe protein (ab116899)参考文献

ab116899 has not yet been referenced specifically in any publications.

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