Recombinant人LOX 1 protein (ab111627)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP78380
    • 种属Human
    • 序列MQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIE TLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYL FSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLS RRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCI LAAFSICQKKANLRAQ
    • 分子量25 kDa
    • 氨基酸58 to 273

技术指标

Our Abpromise guarantee covers the use of ab111627 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 5% Glycerol, 2.4% Urea

常规信息

  • 别名
    • C-type lectin domain family 8 member A
    • CLEC8A
    • hLOX 1
    • hLOX-1
    • Lectin like oxidized LDL receptor 1
    • Lectin like oxLDL receptor 1
    • Lectin type oxidized LDL receptor 1
    • Lectin-like oxidized LDL receptor 1
    • Lectin-like oxLDL receptor 1
    • Lectin-type oxidized LDL receptor 1
    • low density lipoprotein oxidized, receptor 1
    • LOX-1
    • LOXIN
    • Olr1
    • OLR1_HUMAN
    • Ox LDL receptor 1
    • Ox-LDL receptor 1
    • Oxidised low density lipoprotein (lectin like) receptor 1
    • Oxidized low density lipoprotein receptor 1
    • Oxidized low density lipoprotein receptor 1 soluble form
    • Oxidized low-density lipoprotein receptor 1
    • SCARE1
    • Scavenger receptor class E, member 1
    • SLOX1
    • soluble form
    • SR-EI
    see all
  • 功能Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
  • 组织特异性Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level.
  • 疾病相关Note=Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.
    Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not.
  • 序列相似性Contains 1 C-type lectin domain.
  • 结构域The cytoplasmic region is required for subcellular sorting on the cell surface.
    The C-type lectin domain mediates the recognition and binding of oxLDL.
  • 翻译后修饰The intrachain disulfide-bonds prevent N-glycosylation at some sites.
    N-glycosylated.
  • 细胞定位Cell membrane. Secreted. A secreted form also exists.
  • Information by UniProt

Recombinant Human LOX 1 protein 图像

  • 15% SDS-PAGE showing ab111627 at approximately 24.7kDa (3µg).

Recombinant Human LOX 1 protein (ab111627)参考文献

ab111627 has not yet been referenced specifically in any publications.

Product Wall

I can confirm that the labs have not yet tested these products to determine activity. They have informed me that ab152043 has been tested successfully by a customer however we cannot share the customer's name or data.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"