Recombinant人Loricrin protein (ab114261)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP23490
    • 种属Human
    • 序列MSYQKKQPTPQPPVDCVKTSGGGGGGGGGGGGGCGFFGGGGSGGGSSGSG CGYSGGGGYSGGGCG GGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSG GGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFS SGGGGSSGGGSGCFSS GGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGGSG GGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGC FSSGGGGGSSGCGGGS SGIGSGCIISGGGSVCGGGSSGGGGGGSSVGG SGSGKGVPICHQTQQKQAPTWPSK
    • 分子量61 kDa including tags
    • 氨基酸1 to 316

技术指标

Our Abpromise guarantee covers the use of ab114261 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 µg/µl
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • LOR
    • LOR protein
    • LORI_HUMAN
    • Loricrin
    • LRN
    • MGC111513
    • OTTHUMP00000015823
    see all
  • 功能Major keratinocyte cell envelope protein.
  • 疾病相关Defects in LOR are a cause of progressive symmetric erythrokeratodermia (PSEK) [MIM:133200]. Erythrokeratodermas are a group of disorders characterized by widespread erythematous plaques, either stationary or migratory, associated with features that include palmoplantar keratoderma. PSEK is characterized by erythematous and hyperkeratotic plaques.
    Defects in LOR are the cause of Vohwinkel syndrome with ichthyosis (VSI) [MIM:604117]; also known as loricrin keratoderma (LK) or mutilating keratoderma with ichthyosis. VSI is an ichthyotic variant of Vohwinkel syndrome (VS) characterized by progressive symmetric erythrokeratoderma or congenital ichthyosiform erythroderma born as a collodion baby. Common clinical features include hyperkeratosis of the palms and soles with digital constriction.
  • 翻译后修饰Substrate of transglutaminases. Some glutamines and lysines are cross-linked to other loricrin molecules and to SPRRs proteins.
    Contains inter- or intramolecular disulfide-bonds.
  • 细胞定位Cytoplasm. Nucleus > nucleoplasm.
  • Information by UniProt

Recombinant Human Loricrin protein 图像

  • ab114261 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

Recombinant Human Loricrin protein (ab114261)参考文献

ab114261 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114261.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"