Recombinant人LKB1 protein (ab119736)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionQ15831
    • 种属Human
    • 分子量85 kDa including tags
    • 氨基酸1 to 433

技术指标

Our Abpromise guarantee covers the use of ab119736 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.
    The purity was determined to be 90% by densitometry
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.003% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.29% Sodium chloride

常规信息

  • 别名
    • hLKB1
    • Liver kinase B1
    • LKB1
    • PJS
    • Polarization related protein LKB1
    • Renal carcinoma antigen NY-REN-19
    • Serine/Threonine Kinase 11
    • Serine/threonine protein kinase 11
    • Serine/threonine protein kinase LKB1
    • Serine/threonine protein kinase STK11
    • Serine/threonine-protein kinase 11
    • Serine/threonine-protein kinase LKB1
    • Serine/threonine-protein kinase XEEK1
    • Stk11
    • STK11_HUMAN
    see all
  • 功能Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.
  • 组织特异性Ubiquitously expressed. Strongest expression in testis and fetal liver.
  • 疾病相关Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer.
    Defects in STK11 have been associated with testicular tumors (TEST) [MIM:273300]. A common solid malignancy in males. Germ cell tumors of the testis constitute 95% of all testicular neoplasms.
  • 序列相似性Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰Phosphorylated by a cAMP-dependent protein kinase.
  • 细胞定位Nucleus. Cytoplasm. Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2.
  • Information by UniProt

Recombinant Human LKB1 protein 图像

  • The purity was determined to be >90% by densitometry.

Recombinant Human LKB1 protein (ab119736)参考文献

ab119736 has not yet been referenced specifically in any publications.

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