Recombinant人Lipoamide Dehydrogenase protein (ab93679)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human

技术指标

Our Abpromise guarantee covers the use of ab93679 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

  • 纯度
    > 95 % SDS-PAGE.
    ab93679 is purified using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • Dehydrogenase complex, E3 component
    • Diaphorase
    • Dihydrolipoamide dehydrogenase
    • Dihydrolipoyl dehydrogenase
    • Dihydrolipoyl dehydrogenase mitochondrial
    • dld
    • DLDD
    • DLDH
    • DLDH_HUMAN
    • E3
    • E3 branched chain aplha-keto acid
    • E3 component of pyruvate dehydrogenase
    • E3 component of pyruvate dehydrogenase complex 2 oxo glutarate complex branched chain keto acid dehydrogenase complex
    • GCSL
    • Glycine cleavage system L protein
    • Glycine cleavage system protein L
    • LAD
    • lipoamide dehydrogenase
    • Lipoamide reductase
    • Lipoyl dehydrogenase
    • mitochondrial
    • OTTHUMP00000206744
    • OTTHUMP00000206746
    • OTTHUMP00000206748
    • OTTHUMP00000206749
    • PHE 3
    • PHE3
    • Pyruvate dehydrogenase component E3
    see all
  • 功能
    Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.
  • 疾病相关
    Note=Defects in DLD are involved in the development of congenital infantile lactic acidosis.
    Defects in DLD are a cause of maple syrup urine disease (MSUD) [MIM:248600]. MSUD is characterized by mental and physical retardation, feeding problems and a maple syrup odor to the urine. The keto acids of the branched-chain amino acids are present in the urine, resulting from a block in oxidative decarboxylation.
  • 序列相似性
    Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  • 翻译后修饰
    Tyrosine phosphorylated.
  • 细胞定位
    Mitochondrion matrix.
  • Information by UniProt

图片

  • 15% SDS-PAGE analysis of ab93679 (3µg).

文献

ab93679 has not yet been referenced specifically in any publications.

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