Recombinant人LAT protein (ab113124)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionO43561-2
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMHCHRLPGSYDSTSSDSLYPRGIQFKRPHT VAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSDGANS VASYENEEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTP GIRDSAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTE PAALSSQEAEEVEEEGAPDYENLQELN
    • 分子量24 kDa including tags
    • 氨基酸28 to 233
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113124 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 95 % SDS-PAGE.
    ab113124 was purified using conventional chromatography.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT

常规信息

  • 别名
    • 36 kDa phospho tyrosine adapter protein
    • 36 kDa phospho-tyrosine adapter protein
    • 36 kDa phospho-tyrosine adaptor protein
    • lat
    • LAT 1
    • LAT_HUMAN
    • LAT1
    • Linker for activation of T cells
    • Linker for activation of T cells family member 1
    • linker for activation of T cells, transmembrane adaptor
    • Linker for activation of T-cells family member 1
    • p36 38
    • p36-38
    • pp36
    see all
  • 功能Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
  • 组织特异性Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level).
  • 翻译后修饰Phosphorylated on tyrosines by ZAP-70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ.
    Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation.
  • 细胞定位Cell membrane. Present in lipid rafts.
  • Information by UniProt

Recombinant Human LAT protein 图像

  • 15% SDS-PAGE analysis of ab113124 (3 µg).
    Molecular weight on SDS-PAGE will appear higher.

Recombinant Human LAT protein (ab113124)参考文献

ab113124 has not yet been referenced specifically in any publications.

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