Recombinant人Laminin 2 alpha protein (ab114155)

概述

  • 产品名称Recombinant人Laminin 2 alpha protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP24043
    • 种属Human
    • 序列DAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTND PVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELR GVQPVSCPAN
    • 分子量38 kDa including tags
    • 氨基酸3013 to 3122

技术指标

Our Abpromise guarantee covers the use of ab114155 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式Liquid
  • 补充说明protein concentration is above or equal to 0.05 mg/ml.
    ab114155 is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • LAMA 2
    • LAMA2
    • LAMA2_HUMAN
    • Laminin alpha 2
    • Laminin alpha 2 (merosin congenital muscular dystrophy)
    • Laminin alpha 2 chain
    • Laminin alpha 2 subunit
    • Laminin M
    • Laminin M chain
    • Laminin subunit alpha-2
    • Laminin-12 subunit alpha
    • Laminin-2 subunit alpha
    • Laminin-4 subunit alpha
    • LAMM
    • Merosin heavy chain
    see all
  • 功能Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 组织特异性Placenta, striated muscle, peripheral nerve, cardiac muscle, pancreas, lung, spleen, kidney, adrenal gland, skin, testis, meninges, choroid plexus, and some other regions of the brain; not in liver, thymus and bone.
  • 疾病相关Defects in LAMA2 are the cause of merosin-deficient congenital muscular dystrophy type 1A (MDC1A) [MIM:607855]. MDC1A is characterized by difficulty walking, hypotonia, proximal weakness, hyporeflexia, and white matter hypodensity on MRI.
  • 序列相似性Contains 17 laminin EGF-like domains.
    Contains 5 laminin G-like domains.
    Contains 2 laminin IV type A domains.
    Contains 1 laminin N-terminal domain.
  • 结构域The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
    Domains VI, IV and G are globular.
  • 细胞定位Secreted > extracellular space > extracellular matrix > basement membrane. Major component.
  • Information by UniProt

Recombinant Human Laminin 2 alpha protein 图像

  • 12.5% SDS-PAGE analysis of ab114155, stained with Coomassie Blue.

Recombinant Human Laminin 2 alpha protein (ab114155)参考文献

ab114155 has not yet been referenced specifically in any publications.

Product Wall

The human Laminin 2 alpha protein fragment ab114155 is not the full-length protein. It is a fragment, from amino acids 3013 - 3122 of the sequence given at the UniProt database entry for human Laminin subunit alpha-2, http://www.uniprot.org/uniprot/P24...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"