Recombinant人Lamin B1 protein (ab114163)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP20700
    • 种属Human
    • 序列MATATPVPPRMGSRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKV RSLETENSALQLQVTEREEVRGRELTGLKALYETELADARRALDDTARER AKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAALA TALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQS LTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMR EQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRI ESLSSQLSNLQKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAE IRDQMQQQLNDYEQLLDVKLALDMEIS AYRKLLQGEEERLKLSPSPSS RVTVSRASSSRSVRTTRGKRKRVDVEESEASSSVSISHSASATGNVCIEE IDVD GKFIRLKNTSEQDQPMGGWEMIRKIGDTSVSYKYTSRYVLKAGQ TVTIWAANAGVTASPPTDLIWKNQNSWGTGE DVKVILKNSQGEEVAQR STVFKTTIPEEEEEEEEAAGVVVEEELFHQQGTPRASNRSCAIM
    • 分子量91 kDa including tags
    • 氨基酸1 to 586

技术指标

Our Abpromise guarantee covers the use of ab114163 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    ab114163 is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • ADLD
    • lamin B1
    • Lamin-B1
    • LMN
    • LMN2
    • LMNB
    • Lmnb1
    • LMNB1_HUMAN
    • MGC111419
    • OTTHUMP00000159218
    see all
  • 功能Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
  • 疾病相关Defects in LMNB1 are the cause of leukodystrophy demyelinating autosomal dominant adult-onset (ADLD) [MIM:169500]. ADLD is a slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosis.
  • 序列相似性Belongs to the intermediate filament family.
  • 翻译后修饰B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
  • 细胞定位Nucleus inner membrane.
  • Information by UniProt

Recombinant Human Lamin B1 protein 图像

  • 12.5% SDS-PAGE analysis of ab114163, stained with Coomassie Blue.

Recombinant Human Lamin B1 protein (ab114163)参考文献

ab114163 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114163.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"