Recombinant人l Afadin protein (ab91389)

概述

  • 产品名称Recombinant人l Afadin protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 氨基酸1 to 141

技术指标

Our Abpromise guarantee covers the use of ab91389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 50mM Sodium chloride, 25mM HEPES, 1mM EDTA, pH 7.5

常规信息

  • 别名
    • AF6
    • AFAD_HUMAN
    • Afadin
    • ALL1-fused gene from chromosome 6 protein
    • Mllt4
    • Protein Af-6
    • Protein AF6
    see all
  • 功能Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
  • 疾病相关Note=A chromosomal aberration involving MLLT4 is associated with acute leukemias. Translocation t(6;11)(q27;q23) with MLL/HRX. The result is a rogue activator protein.
  • 序列相似性Contains 1 dilute domain.
    Contains 1 FHA domain.
    Contains 1 PDZ (DHR) domain.
    Contains 2 Ras-associating domains.
  • 结构域The PDZ/DHR domain interacts with the C-terminus of nectin and the Pro-rich N-terminus domain interacts with F-actin.
  • 细胞定位Cell junction > adherens junction. Not found at cell-matrix AJs.
  • Information by UniProt

Recombinant Human l Afadin protein (ab91389)参考文献

ab91389 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab91389.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"