Recombinant人Kv1.1 potassium channel protein (ab114350)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      NFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKYEYMEIEE DMNNSIAHYRQVNIRTANCTTANQNCVNKSKLLTDV
    • 分子量
      35 kDa including tags
    • 氨基酸
      410 to 495

技术指标

Our Abpromise guarantee covers the use of ab114350 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • AEMK
    • EA1
    • Episodic ataxia with myokymia
    • HBK1
    • HUK1
    • Kca1 1
    • Kcna1
    • KCNA1_HUMAN
    • Kcpvd
    • KV1.1
    • MBK1
    • mceph
    • MGC124402
    • MGC126782
    • MGC138385
    • MK1
    • MK1, mouse, homolog of KV1.1
    • Potassium channel protein 1
    • Potassium voltage gated channel shaker related subfamily member 1
    • Potassium voltage gated channel subfamily A member 1
    • Potassium voltage gated channel, shaker related subfamily, member 1 (episodic ataxia with myokymia)
    • Potassium voltage-gated channel subfamily A member 1
    • RBK1
    • RCK1
    • Shak
    • Shaker related subfamily member 1
    • Voltage gated potassium channel subunit Kv1.1
    • Voltage-gated K(+) channel HuKI
    • Voltage-gated potassium channel HBK1
    • Voltage-gated potassium channel subunit Kv1.1
    see all
  • 功能
    Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
  • 疾病相关
    Defects in KCNA1 are the cause of episodic ataxia type 1 (EA1) [MIM:160120]; also known as paroxysmal or episodic ataxia with myokymia (EAM) or paroxysmal ataxia with neuromyotonia. EA1 is an autosomal dominant disorder characterized by brief episodes of ataxia and dysarthria. Neurological examination during and between the attacks demonstrates spontaneous, repetitive discharges in the distal musculature (myokymia) that arise from peripheral nerve. Nystagmus is absent.
    Defects in KCNA1 are the cause of myokymia isolated type 1 (MK1) [MIM:160120]. Myokymia is a condition characterized by spontaneous involuntary contraction of muscle fiber groups that can be observed as vermiform movement of the overlying skin. Electromyography typically shows continuous motor unit activity with spontaneous oligo- and multiplet-discharges of high intraburst frequency (myokymic discharges). Isolated spontaneous muscle twitches occur in many persons and have no grave significance.
  • 序列相似性
    Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.1/KCNA1 sub-subfamily.
  • 结构域
    The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • 翻译后修饰
    Palmitoylated on Cys-243; which may be required for membrane targeting.
  • 细胞定位
    Membrane.
  • Information by UniProt

图片

  • ab114350 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

文献

ab114350 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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