Recombinant人KLF6 protein (ab114550)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ99612
    • 种属Human
    • 序列MDVLPMCSIFQELQIVHETGYFSALPSLEEYWQQTCLELERYLQSEPCYV SASEIKFDSQEDLWTKIILAREKKEESELKISSSPPEDTLISPSFCYNLE TNSLNSDVSSESSDSSEELSPTAKFTSDPIGEVLVSSGKLGSSVTSAPPS SPELSREPSQLWGCVPGELPSPGKVRSGTSGKPGDKGNGDASPDGRRRVH RCHFNGCRKVYTKSSHLKAHQRTHTGEKPYRCSWEGCEWRFARSDELTRH FRKHTGAKPF
    • 分子量55 kDa including tags
    • 氨基酸1 to 261

相关产品

技术指标

Our Abpromise guarantee covers the use of ab114550 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • B cell derived protein 1
    • B cell-derived 1
    • B-cell-derived protein 1
    • BCD1
    • CBA1
    • COPEB
    • Core promoter element-binding protein
    • CPBP
    • GBF
    • GC rich binding factor
    • GC rich sites binding factor GBF
    • GC-rich sites-binding factor GBF
    • Klf6
    • KLF6_HUMAN
    • Krueppel-like factor 6
    • Krueppel-like factor 6 isoform C
    • Kruppel like zinc finger protein Zf9
    • PAC1
    • Proto-oncogene BCD1
    • Protooncogene B cell derived 1
    • ST12
    • Suppression of tumorigenicity 12 (prostate)
    • Suppressor of tumorigenicity 12 protein
    • Transcription factor Zf9
    • Zf9
    see all
  • 功能Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.
  • 组织特异性Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.
  • 疾病相关Defects in KLF6 are a cause of gastric cancer (GASC) [MIM:613659]; also called gastric cancer intestinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
    Defects in KLF6 are a cause of prostate cancer (PC) [MIM:176807]. Prostate cancer is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
  • 序列相似性Belongs to the krueppel C2H2-type zinc-finger protein family.
    Contains 3 C2H2-type zinc fingers.
  • 结构域The acidic N-terminal part may favor interaction with the basic domain of transcription factors.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human KLF6 protein 图像

  • 12.5% SDS-PAGE Stained with Coomassie Blue showing ab114550

Recombinant Human KLF6 protein (ab114550)参考文献

ab114550 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114550.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"