概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ15726
    • 种属Human
    • 序列MEPLEKVASV GNSRPTGQQL ESLGLLAPGE QSLPCTERKP AATARLSRRG TSLSPPPESS GSPQQPGLSA PHSRQIPAPQ GAVLVQREKD LPNYNWNSFG LRFGKREAAP GNHGRSAGRG
    • 分子量13 kDa
    • 氨基酸20 to 138

技术指标

Our Abpromise guarantee covers the use of ab117209 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.
    ab117209 was purified by proprietary chromatographic techniques and filter sterilized.
  • 形式Liquid
  • 补充说明ab117209 although stable at 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol

常规信息

  • 别名
    • KISS 1
    • KiSS 1 metastasis suppressor
    • Kiss1
    • KISS1_HUMAN
    • Kisspeptin
    • Kisspeptin 1
    • Kisspeptin 10
    • Kisspeptin 13
    • Kisspeptin 14
    • Kisspeptin-1
    • Kisspeptin-10
    • Kisspeptin-54
    • Kisspeptin1
    • Malignant melanoma metastasis suppressor
    • Metastasis suppressor KiSS 1
    • Metastasis suppressor KiSS1
    • Metastin
    • MGC39258
    see all
  • 功能Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
  • 组织特异性Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast.
  • 序列相似性Belongs to the KISS1 family.
  • 翻译后修饰Processed by MMP2 and MMP9.
  • 细胞定位Secreted.
  • Information by UniProt

Recombinant Human Kisspeptin protein (ab117209)参考文献

This product has been referenced in:
  • Stathaki M  et al. Kisspeptin effect on endothelial monocyte activating polypeptide II (EMAP-II)-associated lymphocyte cell death and metastases in colorectal cancer patients. Mol Med 20:80-92 (2014). Read more (PubMed: 24395571) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab117209.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"