Recombinant人Kir4.1 protein (ab114456)

概述

  • 产品名称
    Recombinant人Kir4.1 protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      DFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYIA DFSLFDQVVKVASPSGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVR ISNV
    • 分子量
      37 kDa including tags
    • 氨基酸
      276 to 379

技术指标

Our Abpromise guarantee covers the use of ab114456 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

    ELISA

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml.
    ab114456 is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • ATP dependent inwardly rectifying potassium channel Kir4.1
    • ATP sensitive inward rectifier potassium channel 10
    • ATP-dependent inwardly rectifying potassium channel Kir4.1
    • ATP-sensitive inward rectifier potassium channel 10
    • BIRK10
    • Glial ATP dependent inwardly rectifying potassium channel KIR4.1
    • Inward rectifier K(+) channel Kir1.2
    • Inward rectifier K+ channel KIR1.2
    • Inwardly rectifying potassium channel Kir1.2
    • inwardly rectifying subfamily J member 10
    • KCJ10_HUMAN
    • KCNJ 10
    • Kcnj10
    • KCNJ13 PEN
    • KIR1.2
    • KIR4.1
    • Potassium channel
    • Potassium channel inwardly rectifying subfamily J member 10
    • Potassium inwardly rectifying channel subfamily J member 10
    • SESAME
    see all
  • 功能
    May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules.
  • 组织特异性
    Expressed in kidney (at protein level).
  • 疾病相关
    Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance
  • 序列相似性
    Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.
  • 细胞定位
    Membrane. Basolateral cell membrane. In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16.
  • Information by UniProt

图片

  • ab114456 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

文献

ab114456 has not yet been referenced specifically in any publications.

客户评价及客户问答


Unfortunately, we cannot sell this product to you because of Dry Ice shipping restriction to Norway.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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