Recombinant人Kir2.1 protein (ab114391)

概述

  • 产品名称Recombinant人Kir2.1 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP63252
    • 种属Human
    • 序列PVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYE NEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRPLRRESEI
    • 分子量37 kDa including tags
    • 氨基酸328 to 427

技术指标

Our Abpromise guarantee covers the use of ab114391 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    ab114391 is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • Cardiac inward rectifier potassium channel
    • HHBIRK 1
    • HHBIRK1
    • HHIRK 1
    • HHIRK1
    • HIRK 1
    • hIRK1
    • Inward rectifier K
    • Inward rectifier K(+) channel Kir2.1
    • Inward rectifier potassium channel 2
    • inwardly rectifying subfamily J member 2
    • IRK 1
    • IRK-1
    • IRK1
    • IRK2_HUMAN
    • KCNJ2
    • KIR2.1
    • LQT 7
    • LQT7
    • Potassium channel
    • Potassium channel inwardly rectifying subfamily J member 2
    • Potassium inwardly rectifying channel J2
    • Potassium inwardly rectifying channel subfamily J member 2
    • SQT 3
    • SQT3
    see all
  • 功能Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.
  • 组织特异性Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
  • 疾病相关Defects in KCNJ2 are the cause of long QT syndrome type 7 (LQT7) [MIM:170390]; also called Andersen syndrome or Andersen cardiodysrhythmic periodic paralysis. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. LQT7 manifests itself as a clinical triad consisting of potassium-sensitive periodic paralysis, ventricular ectopy and dysmorphic features.
    Defects in KCNJ2 are the cause of short QT syndrome type 3 (SQT3) [MIM:609622]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death. SQT3 has a unique ECG phenotype characterized by asymmetrical T waves.
  • 序列相似性Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.
  • 细胞定位Membrane.
  • Information by UniProt

Recombinant Human Kir2.1 protein 图像

  • ab114391 analysed on a 12.5% SDS-PAGE Stained with Coomassie Blue.

Recombinant Human Kir2.1 protein (ab114391)参考文献

ab114391 has not yet been referenced specifically in any publications.

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