Recombinant人KDM5A / Jarid1A / RBBP2 protein (ab112347)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP29375
    • 种属Human
    • 序列KVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQ IFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNF
    • 分子量37 kDa including tags
    • 氨基酸191 to 290
    • 标签GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab112347 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性useful for Antibody Production and Protein Array
  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl
    Note: Glutathione is reduced

常规信息

  • 别名
    • Histone demethylase JARID1A
    • JARID1A
    • Jumonji/ARID domain containing protein 1A
    • Jumonji/ARID domain-containing protein 1A
    • Kdm5a
    • KDM5A_HUMAN
    • Lysine-specific demethylase 5A
    • RBBP-2
    • RBBP2
    • RBP2
    • Retinoblastoma binding protein 2
    • Retinoblastoma-binding protein 2
    see all
  • 功能Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12.
  • 序列相似性Belongs to the JARID1 histone demethylase family.
    Contains 1 ARID domain.
    Contains 1 JmjC domain.
    Contains 1 JmjN domain.
    Contains 3 PHD-type zinc fingers.
  • 结构域The GSGFP motif is required for the interaction with SUZ12.
  • 细胞定位Nucleus > nucleolus. Occupies promoters of genes involved in RNA metabolism and mitochondrial function.
  • Information by UniProt

Recombinant Human KDM5A / Jarid1A / RBBP2 protein 图像

  • 12.5% SDS-PAGE showing ab112347 at approximately 36.63kDa stained with Coomassie Blue.

Recombinant Human KDM5A / Jarid1A / RBBP2 protein (ab112347)参考文献

ab112347 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"