Recombinant人KCNJ1 protein (ab114590)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP48048
    • 种属Human
    • 序列ELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDF HNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
    • 分子量37 kDa including tags
    • 氨基酸292 to 391

技术指标

Our Abpromise guarantee covers the use of ab114590 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 µg/ul. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • ATP regulated potassium channel ROM K
    • ATP sensitive inward rectifier potassium channel 1
    • ATP-regulated potassium channel ROM-K
    • ATP-sensitive inward rectifier potassium channel 1
    • Inward rectifier K(+) channel Kir1.1
    • inwardly rectifying K+ channel
    • inwardly rectifying subfamily J member 1
    • IRK1_HUMAN
    • KCNJ
    • KCNJ 1
    • Kcnj1
    • Kir 1.1
    • Kir1.1
    • OTTHUMP00000045938
    • Potassium channel
    • Potassium channel inwardly rectifying subfamily J member 1
    • potassium inwardly-rectifying channel J1
    • ROMK
    • ROMK 1
    • ROMK 2
    • ROMK1
    • ROMK2
    see all
  • 功能In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.
  • 组织特异性In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver.
  • 疾病相关Defects in KCNJ1 are the cause of Bartter syndrome type 2 (BS2) [MIM:241200]; also termed hyperprostanglandin E syndrome 2. BS refers to a group of autosomal recessive disorders characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. BS2 is a life-threatening condition beginning in utero, with marked fetal polyuria that leads to polyhydramnios and premature delivery. Another hallmark of BS2 is a marked hypercalciuria and, as a secondary consequence, the development of nephrocalcinosis and osteopenia.
  • 序列相似性Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily.
  • 细胞定位Membrane.
  • Information by UniProt

Recombinant Human KCNJ1 protein 图像

  • 12.5% SDS-PAGE showing ab114590 at approximately 36.63kDa stained with Coomassie Blue.

Recombinant Human KCNJ1 protein (ab114590)参考文献

ab114590 has not yet been referenced specifically in any publications.

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