概述

  • 产品名称
    重组人KCNH2蛋白
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • 种属
      Human
    • 序列
      LGMGWGAGTGLEMPSAASRGASLLNMQSLGLWTWDCLQGHWAPLIHLNSG PPSGAMERSPTWGEAAELWGSHILLPFRIRHKQTLFASLK
    • 分子量
      36 kDa including tags

技术指标

Our Abpromise guarantee covers the use of ab152488 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • eag homolog
    • Eag-related protein 1
    • ERG
    • ERG-1
    • ERG1
    • Ether a go go related potassium channel protein
    • Ether-a-go-go-related gene potassium channel 1
    • Ether-a-go-go-related protein 1
    • H ERG
    • H-ERG
    • HERG
    • HERG 1
    • hERG-1
    • hERG1
    • KCNH2
    • KCNH2_HUMAN
    • Kv11.1
    • LQT 2
    • LQT2
    • Potassium channel HERG
    • Potassium voltage gated channel subfamily H (eag related) member 2
    • Potassium voltage-gated channel subfamily H member 2
    • SQT1
    • Voltage gated potassium channel, subfamily H, member 2
    • Voltage-gated potassium channel subunit Kv11.1
    see all
  • 功能
    Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
  • 组织特异性
    Highly expressed in heart and brain.
  • 疾病相关
    Defects in KCNH2 are the cause of long QT syndrome type 2 (LQT2) [MIM:613688]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. Deafness is often associated with LQT2.
    Defects in KCNH2 are the cause of short QT syndrome type 1 (SQT1) [MIM:609620]. Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death.
  • 序列相似性
    Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
    Contains 1 cyclic nucleotide-binding domain.
    Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 1 PAS (PER-ARNT-SIM) domain.
  • 结构域
    The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.
  • 翻译后修饰
    Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction.
  • 细胞定位
    Membrane.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab152488 stained with Coomassie Blue.

文献

ab152488 has not yet been referenced specifically in any publications.

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