The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab116481 is purified by proprietary chromatographic techniques.
补充说明although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days. Please avoid freeze-thaw cycles.
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Shipped at 4°C. Please see notes section.
pH: 8.00 Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol
Histidine aminotransferase 1
Histone acetyltransferase 1
Histone acetyltransferase type B catalytic subunit
功能Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.
序列相似性Belongs to the HAT1 family.
发展阶段Highly expressed in mitotic cells (at protein level).
细胞定位Nucleus matrix and Cytoplasm. Nucleus. Nucleus matrix. Nucleus > nucleoplasm. Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.