Recombinant人KAT1 / HAT1 protein (ab116481)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionO14929
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMKKLAEYKCNTNTAIELKLVRFPEDLENDI RTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTMFRVEYASKVDEN FDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKEVDFKPFGTLLHTYSV LSPTGGENFTFQIYKADMTCRGFREYHERLQTFLMWFIETASFIDVDDER WHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQ GQGHGAQLLETVHRYYTEFPTVLDITAEDPSKSYVKLRDFVLVKLCQDLP CFSREKLMQGFNEDMAIEAQQKFKINKQHARRVYEILRLLVTD
    • 分子量40 kDa including tags
    • 氨基酸20 to 341
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab116481 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.
    ab116481 is purified by proprietary chromatographic techniques.
  • 形式Liquid
  • 补充说明although stable at 4°C for 30 days, should be stored desiccated below -20°C for periods greater than 30 days. Please avoid freeze-thaw cycles.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol

常规信息

  • 别名
    • HAT 1
    • hat1
    • HAT1_HUMAN
    • Histidine aminotransferase 1
    • Histone acetyltransferase 1
    • Histone acetyltransferase type B catalytic subunit
    • KAT1
    see all
  • 功能Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.
  • 序列相似性Belongs to the HAT1 family.
  • 发展阶段Highly expressed in mitotic cells (at protein level).
  • 细胞定位Nucleus matrix and Cytoplasm. Nucleus. Nucleus matrix. Nucleus > nucleoplasm. Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein.
  • Information by UniProt

Recombinant Human KAT1 / HAT1 protein (ab116481)参考文献

ab116481 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"