Recombinant人Kallikrein 7 protein (ab114437)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP49862
    • 种属Human
    • 序列IDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHL GSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKK
    • 分子量37 kDa including tags
    • 氨基酸31 to 130

技术指标

Our Abpromise guarantee covers the use of ab114437 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Chymotryptic stratum corneum
    • hK 7
    • hK7
    • hSCCE
    • Kallikrein 7 (chymotryptic stratum corneum)
    • Kallikrein related peptidase 7
    • Kallikrein-7
    • Kallikrein7
    • KLK 7
    • Klk7
    • KLK7_HUMAN
    • Protease serine 6
    • PRSS 6
    • PRSS6
    • SCCE
    • Serine protease 6
    • Signal protein
    • Stratum corneum chymotryptic enzyme
    see all
  • 功能May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-
    -Cys-7', '16-Tyr-
    -Leu-17', '25-Phe-
    -Tyr-26' and '26-Tyr-
    -Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
  • 组织特异性Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level).
  • 序列相似性Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.
  • 细胞定位Secreted. In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.
  • Information by UniProt

Recombinant Human Kallikrein 7 protein 图像

  • ab114437 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human Kallikrein 7 protein (ab114437)参考文献

ab114437 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114437.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"