Recombinant人JAB1 protein (ab92007)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列QKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISA LALLKMVMHAR SGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRV NAQAAAYEYMAAYIENAKQVGRLE NAIGWYHSHPGYGCWLSGIDVSTQ MLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKG YKPPDEGPSEY QTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSS SLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLA KATRDSCKTTIEA IHGLMSQVIKDKLFNQINIS
    • 氨基酸10 to 334

技术指标

Our Abpromise guarantee covers the use of ab92007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 形式Lyophilised
  • 补充说明Protein Identity confirmed by Mass Spectrometry (MS/MS) (acquired on initial reference batch).
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5

  • 复溶Reconstitute with 104 µl aqua dest.

常规信息

  • 别名
    • 38 kDa Mov34 homolog
    • COP9 (constitutive photomorphogenic) homolog subunit 5
    • COP9 constitutive photomorphogenic homolog subunit 5
    • COP9 signalosome complex subunit 5
    • COP9 signalosome subunit 5
    • Cop9 subunit 5
    • COPS 5
    • cops5
    • CSN 5
    • CSN5
    • CSN5_HUMAN
    • JAB 1
    • Jun activation domain binding protein
    • Jun activation domain binding protein 1
    • Jun activation domain-binding protein 1
    • MGC3149
    • MOV 34
    • MOV34
    • MOV34 family, 38-KD member
    • SGN 5
    • SGN5
    • Signalosome subunit 5
    see all
  • 功能Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex.
  • 序列相似性Belongs to the peptidase M67A family. CSN5 subfamily.
    Contains 1 MPN (JAB/Mov34) domain.
  • 结构域The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt

Recombinant Human JAB1 protein 图像

  • The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images coloured control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.

Recombinant Human JAB1 protein (ab92007)参考文献

ab92007 has not yet been referenced specifically in any publications.

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