Recombinant人IRE1 protein (ab114174)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionO75460
    • 种属Human
    • 序列EEVINLVDQTSENAPTTVSRDVEEKPAHAPARPEAPVDSMLKDMATIILS TFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQQQQQLPFHP
    • 分子量37 kDa including tags
    • 氨基酸401 to 500

技术指标

Our Abpromise guarantee covers the use of ab114174 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Endoplasmic reticulum (ER) to nucleus signalling 1
    • Endoplasmic reticulum to nucleus signaling 1
    • Endoplasmic reticulum-to-nucleus signaling 1
    • Endoribonuclease
    • ER to nucleus signaling 1
    • ERN 1
    • Ern1
    • ERN1_HUMAN
    • hIRE 1p
    • hIRE1p
    • Inositol requiring 1
    • Inositol requiring 1, S. cerevisiae, homolog of
    • Inositol requiring enzyme 1, S. cerevisiae, homolog of
    • Inositol requiring protein 1
    • inositol-requiring enzyme 1
    • Inositol-requiring protein 1
    • IRE 1
    • IRE 1a
    • IRE 1P
    • Ire1 alpha
    • Ire1-alpha
    • IRE1a
    • Ire1alpha
    • IRE1P
    • MGC163277
    • MGC163279
    • Protein kinase/endoribonuclease
    • RGD1559716
    • Serine/threonine protein kinase/endoribonuclease IRE1
    see all
  • 功能Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.
  • 组织特异性Ubiquitously expressed. High levels observed in pancreatic tissue.
  • 序列相似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    Contains 1 KEN domain.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt

Recombinant Human IRE1 protein 图像

  • ab114174 on a 12.5% SDS-PAGE Stained with Coomassie Blue.

Recombinant Human IRE1 protein (ab114174)参考文献

ab114174 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114174.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"