Recombinant人IRAK4 protein (ab60860)

概述

描述

  • 性质Recombinant
  • 来源Insect cells
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab60860 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Functional Studies

    SDS-PAGE

  • 形式Liquid
  • 补充说明

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • IL-1 receptor-associated kinase 4
    • Interleukin 1 receptor associated kinase 4 mutant form 1
    • Interleukin-1 receptor-associated kinase 4
    • Interleukin1 receptor associated kinase 4
    • IPD1
    • IRAK 4
    • IRAK-4
    • IRAK4
    • IRAK4 mutated form 1
    • IRAK4_HUMAN
    • LOC 51135
    • NY REN 64
    • NY REN 64 antigen
    • NY-REN-64
    • REN64
    • Renal carcinoma antigen NY-REN-64
    see all
  • 功能Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Phosphorylates IRAK1.
  • 疾病相关Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD.
    Defects in IRAK4 are the cause of IRAK4 deficiency (IRAK4D) [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
  • 序列相似性Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
    Contains 1 death domain.
    Contains 1 protein kinase domain.
  • Information by UniProt

Recombinant human IRAK4 protein 图像

  • Sample Kinase Activity Plot.
  • ab60860 on SDS-PAGE, MW ~81 kDa.

Recombinant human IRAK4 protein (ab60860)参考文献

ab60860 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. I can confirm that the N-terminal tag is a GST tag. I have also updated the datasheet to show this information. If there is anything else that I can help you with, please do not hesitate to contact me.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"