重组人Ionotropic Glutamate receptor 4蛋白(ab152441)

概述

  • 产品名称
    重组人Ionotropic Glutamate receptor 4蛋白
  • 蛋白长度
    Full length protein

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFL HNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDK RSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYE WNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEE LDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLE RFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSAL TYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLK QVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQ DVPTLGNDTAAIENRTVVVTTIMPLMKNPILRN
    • 分子量
      76 kDa including tags
    • 氨基酸
      1 to 433
    • 标签
      GST tag N-Terminus
    • 额外的序列信息
      This is Isoform 2 of Glutamte Receptor 4

技术指标

Our Abpromise guarantee covers the use of ab152441 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • AMPA 4
    • AMPA selective glutamate receptor 4
    • AMPA-selective glutamate receptor 4
    • AMPA4
    • GluA 4
    • GluA4
    • GluR 4
    • GluR D
    • GluR-4
    • GluR-D
    • GluR4
    • GLUR4C
    • GLURD
    • Glutamate receptor 4
    • Glutamate receptor ionotrophic AMPA 4
    • Glutamate receptor ionotropic
    • GRIA 4
    • Gria4
    • GRIA4_HUMAN
    see all
  • 功能
    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
  • 序列相似性
    Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily.
  • 翻译后修饰
    Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
  • 细胞定位
    Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab152441 stained with Coomassie Blue.

文献

ab152441 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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