Recombinant人Interferon regulatory factor 9 protein (ab126019)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 分子量
      11 kDa
    • 氨基酸
      239 to 389

技术指标

Our Abpromise guarantee covers the use of ab126019 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 复溶
    Reconstitute with water to desired concentration.

常规信息

  • 别名
    • IFN alpha responsive transcription factor subunit
    • IFN-alpha-responsive transcription factor subunit
    • Interferon regulatory factor 9
    • interferon stimulated transcription factor 3
    • Interferon-stimulated gene factor 3 gamma
    • interferon-stimulated transcription factor 3, gamma 48kDa
    • IRF 9
    • IRF-9
    • Irf9
    • IRF9_HUMAN
    • ISGF 3 gamma
    • ISGF-3 gamma
    • ISGF3
    • ISGF3 p48 subunit
    • ISGF3G
    • OTTHUMP00000164692
    • OTTHUMP00000164693
    • p48
    • Transcriptional regulator ISGF3 subunit gamma
    see all
  • 功能
    Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
  • 序列相似性
    Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • 细胞定位
    Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.
  • Information by UniProt

文献

ab126019 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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