Recombinant人Integrin beta 7 protein (ab114398)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP26010
    • 种属Human
    • 序列PPGVHISYESQCEGPEKREGKAEDRGQCNHVRINQTVTFWVSLQATHCLP EPHLLRLRALGFSEELIVELHTLCDCNCSDTQPQAPHCSDGQGHLQCGVC SCAPG
    • 分子量37 kDa
    • 氨基酸401 to 505

技术指标

Our Abpromise guarantee covers the use of ab114398 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.03% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Gut homing receptor beta subunit
    • Integrin beta 7 subunit
    • Integrin beta-7
    • Integrin beta-P
    • Integrin, beta 7
    • ITB7
    • ITB7_HUMAN
    • Itgb7
    • Ly69
    • M290 IEL antigen
    see all
  • 功能Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
  • 组织特异性Expressed in a variety of leukocyte lines.
  • 序列相似性Belongs to the integrin beta chain family.
    Contains 1 VWFA domain.
  • 结构域Domain I contains three cation-binding sites: the ligand-integrin-binding site (LIMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent to MIDAS site (ADMIDAS). In the absence of a ligand or in calcium-dependent binding, only ADMIDAS is occupied. In magnesium-dependent binding all three sites bind metal ions. LIMBS positively modify ligand binding whereas ADMIDAS negatively modify ligand binding.
  • 细胞定位Membrane.
  • Information by UniProt

Recombinant Human Integrin beta 7 protein 图像

  • 12.5% SDS-PAGE analysis of ab114398, stained with Coomassie Blue.

Recombinant Human Integrin beta 7 protein (ab114398)参考文献

ab114398 has not yet been referenced specifically in any publications.

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