Recombinant人ING1 protein (ab125575)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionQ9UK53-2
    • 种属Human
    • 分子量38 kDa including tags
    • 氨基酸1 to 279
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab125575 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 纯度> 85 % Densitometry.
    Purity determined to be >85% by densitometry.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Preservative: 1.02% Imidazole
    Constituents: 0.002% PMSF, 0.81% Sodium phosphate, 0.0038% DTT, 25% Glycerol, 1.75% Sodium chloride

常规信息

  • 别名
    • 2610028J21Rik
    • AA407184
    • AI875420
    • Growth inhibitor ING 1
    • Growth inhibitor ING1
    • Growth inhibitory protein ING 1
    • Growth inhibitory protein ING1
    • Homo sapiens growth inhibitor p33ING1 (ING1) mRNA, complete cds
    • ING 1
    • Ing1
    • ING1_HUMAN
    • Inhibitor of growth 1
    • Inhibitor of growth family member 1
    • Inhibitor of growth protein 1
    • mING1h
    • OTTHUMP00000018703
    • OTTHUMP00000018704
    • OTTHUMP00000018705
    • OTTHUMP00000018706
    • p24ING1c
    • p33
    • p33 ING1
    • p33ING1
    • p33ING1b
    • p33ING1c
    • p37Ing1b
    • p47
    • p47ING1a
    • Tumor suppressor ING 1
    • Tumor suppressor ING1
    see all
  • 功能Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
  • 组织特异性Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.
  • 疾病相关Defects in ING1 are a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:275355]; also known as squamous cell carcinoma of the head and neck.
  • 序列相似性Belongs to the ING family.
    Contains 1 PHD-type zinc finger.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human ING1 protein 图像

  • SDS-PAGE analysis of ab125575.

Recombinant Human ING1 protein (ab125575)参考文献

ab125575 has not yet been referenced specifically in any publications.

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