重组人IMPDH2蛋白(ab113608)

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概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
      P12268
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMADYLISGGTSYVPDDGLTAQQLFNCGDGL TYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAI AMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDV FEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKN RDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNS IFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSI CITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALG ASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRY FSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
    • 分子量
      58 kDa including tags
    • 氨基酸
      1 to 514
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113608 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度
    > 90 % SDS-PAGE.
    ab113608 was purified using conventional chromatography.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.03% DTT, 20% Glycerol, 0.88% Sodium chloride

常规信息

  • 别名
    • IMDH2_HUMAN
    • IMP (inosine monophosphate) dehydrogenase 2
    • IMP dehydrogenase 2
    • IMP oxireductase 2
    • IMPD 2
    • IMPD2
    • IMPDH 2
    • IMPDH II
    • IMPDH-II
    • Impdh2
    • Inosine 5' monophosphate dehydrogenase 2
    • Inosine 5' phosphate dehydrogenase 2
    • Inosine monophosphate dehydrogenase type II
    • Inosine-5''-monophosphate dehydrogenase 2
    see all
  • 功能
    Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.
  • 组织特异性
    IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
  • 通路
    Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
  • 序列相似性
    Belongs to the IMPDH/GMPR family.
    Contains 2 CBS domains.
  • 翻译后修饰
    The N-terminus is blocked.
  • Information by UniProt

图片

  • SDS-PAGE - IMPDH2 protein (ab113608)
    SDS-PAGE - IMPDH2 protein (ab113608)
    15% SDS-PAGE analysis of ab113608 (3µg)

文献

ab113608 has not yet been referenced specifically in any publications.

发表研究结果有使用 ab113608？请让我们知道，以便我们可以引用本数据表中的参考文章。

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