Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.
IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
Belongs to the IMPDH/GMPR family. Contains 2 CBS domains.