Recombinant人IMPDH1 protein (ab97410)

概述

  • 产品名称Recombinant人IMPDH1 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP20839
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MADYLISGGT GYVPEDGLTA QQLFASADGL TYNDFLILPG FIDFIADEVD LTSALTRKIT LKTPLISSPM DTVTEADMAI AMALMGGIGF IHHNCTPEFQ ANEVRKVKKF EQGFITDPVV LSPSHTVGDV LEAKMRHGFS GIPITETGTM GSKLVGIVTS RDIDFLAEKD HTTLLSEVMT PRIELVVAPA GVTLKEANEI LQRSKKGKLP IVNDCDELVA IIARTDLKKN RDYPLASKDS QKQLLCGAAV GTREDDKYRL DLLTQAGVDV IVLDSSQGNS VYQIAMVHYI KQKYPHLQVI GGNVVTAAQA KNLIDAGVDG LRVGMGCGSI CITQEVMACG RPQGTAVYKV AEYARRFGVP IIADGGIQTV GHVVKALALG ASTVMMGSLL AATTEAPGEY FFSDGVRLKK YRGMGSLDAM EKSSSSQKRY FSEGDKVKIA QGVSGSIQDK GSIQKFVPYL IAGIQHGCQD IGARSLSVLR SMMYSGELKF EKRTMSAQIE GGVHGLHSYE KRLY
    • 分子量58 kDa including tags
    • 氨基酸1 to 514
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab97410 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF-TOF
  • 纯度> 95 % SDS-PAGE.
    ab97410 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0

常规信息

  • 别名
    • IMDH1_HUMAN
    • IMP (inosine monophosphate) dehydrogenase 1
    • IMP dehydrogenase 1
    • IMPD
    • IMPD 1
    • IMPD1
    • IMPDH 1
    • IMPDH I
    • IMPDH-I
    • Impdh1
    • Inosine 5' monophosphate dehydrogenase 1
    • Inosine monophosphate dehydrogenase 1
    • Inosine-5''-monophosphate dehydrogenase 1
    • LCA11
    • RP10
    • sWSS2608
    see all
  • 功能Rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors.
  • 组织特异性IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
  • 通路Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.
  • 疾病相关Defects in IMPDH1 are the cause of retinitis pigmentosa type 10 (RP10) [MIM:180105]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP10 inheritance is autosomal dominant.
  • 序列相似性Belongs to the IMPDH/GMPR family.
    Contains 2 CBS domains.
  • Information by UniProt

Recombinant Human IMPDH1 protein 图像

  • 15% SDS-PAGE showing ab97410 at approximately 57.5kDa (3µg).

Recombinant Human IMPDH1 protein (ab97410)参考文献

ab97410 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab97410.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"