Recombinant人IL6R protein (ab50082)

概述

描述

  • 性质Recombinant
  • 来源HEK 293 cells
  • 氨基酸序列
    • 种属Human
    • 序列LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH ASGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPAPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD
    • 氨基酸20 to 358

技术指标

Our Abpromise guarantee covers the use of ab50082 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Functional Studies

  • 内毒素水平< 0.100 Eu/µg
  • 纯度> 95 % SDS-PAGE.
    ab50082 purity is greater than 98% by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
  • 形式Lyophilised
  • 补充说明ab50082 expression system is HEK 293 cells
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.

  • 复溶Reconstitute to 1mg/ml in distilled water.

常规信息

  • 别名
    • CD 126
    • CD126
    • CD126 antigen
    • gp80
    • IL 6R
    • IL 6R 1
    • IL 6R alpha
    • IL-6 receptor alpha chain
    • IL-6 receptor subunit alpha
    • IL-6R 1
    • IL-6R subunit alpha
    • IL-6R-alpha
    • IL-6RA
    • IL6Q
    • Il6r
    • IL6RA
    • IL6RA_HUMAN
    • IL6RQ
    • Interleukin 6 receptor
    • interleukin 6 receptor, alpha
    • Interleukin-6 receptor subunit alpha
    • Membrane glycoprotein 80
    • MGC30256
    see all
  • 功能Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
    Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity.
  • 组织特异性Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
  • 序列相似性Belongs to the type I cytokine receptor family. Type 3 subfamily.
    Contains 1 fibronectin type-III domain.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • 结构域The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.
    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • 翻译后修饰A short soluble form may also be released from the membrane by proteolysis.
  • 细胞定位Secreted and Basolateral cell membrane.
  • Information by UniProt

Recombinant Human IL6R protein (ab50082)参考文献

ab50082 has not yet been referenced specifically in any publications.

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