额外的序列信息Human IL-12 p40 peptide (aa 23-328) is fused at the C-terminus to a 18 aa linker peptide (GSTSGSGKPGSGEGSTKG) and to the IL23 p19 peptide (aa 20-189) and tagged at the N-terminus to a DDDDK-tag.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Induction of IL-17 secretion by mouse splenocytes.
内毒素水平< 0.100 Eu/µg
% SDS-PAGE. ab109153 is 0.2 µm filtered.
Induction of IL17 secretion by Mouse splenocytes.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituent: 99% PBS
This product is an active protein and may elicit a biological response in vivo, handle with caution.
IL 23 A
IL 23 subunit alpha
IL-23 subunit alpha
Interleukin 23 alpha subunit p19
Interleukin 23 p19 subunit
interleukin 23 subunit alpha
interleukin 23 subunit p19
interleukin six, G CSF related factor
Interleukin-23 subunit alpha
Interleukin-23 subunit p19
JKA3 induced upon T cell activation
功能Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
组织特异性Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
序列相似性Belongs to the IL-6 superfamily.
发展阶段Expressed by newborns dendritic cells.
细胞定位Secreted. Secreted upon association with IL12B.
IL17 secretion by Mouse splenocytes Mononuclear cells isolated from Mouse spleen were cultured with Mouse IL23 in presence or absence of various concentrations of ab109153 for 3 days. Levels of IL17 accumulated in culture supernatants were measured using ELISA.
Recombinant human IL23 protein (ab109153)参考文献
has not yet been referenced specifically in any publications.