来源 Escherichia coli
序列 MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
氨基酸 24 to 177 技术指标
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
内毒素水平 < 0.100 Eu/µg
纯度 > 95
% SDS-PAGE. ab50081 purity was assessed also by HPLC.
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
This protein is the 17.2 kDa secreted isoform of IL1RA.
Concentration information loading... 制备和贮存
Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.
Constituents: 5mM Tris, 25mM Sodium chloride, pH 8
复溶 Reconstitute to 1mg/ml with distilled water.
功能 Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
组织特异性 The intracellular form of IL1RN is predominantly expressed in epithelial cells.
疾病相关 Microvascular complications of diabetes 4 Interleukin 1 receptor antagonist deficiency
细胞定位 Cytoplasm and Secreted.
Information by UniProt
Recombinant Human IL1RA protein 图像
Anti-IL1RA antibody ( ab2573) at 1 µg/ml + Recombinant Human IL1RA protein (ab50081) at 0.01 µg Secondary Goat Anti-Rabbit IgG H&L (HRP) preadsorbed ( ab97080) at 1/5000 dilution Developed using the ECL technique Performed under reducing conditions. Exposure time : 20 seconds
Recombinant Human IL1RA protein (ab50081)参考文献
has not yet been referenced specifically in any publications.
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