Recombinant人IL12RB2 protein (ab116889)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ99665
    • 种属Human
    • 序列CINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLY TEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVN SLGSSSSLPS
    • 分子量38 kDa
    • 氨基酸105 to 214

技术指标

Our Abpromise guarantee covers the use of ab116889 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml. This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • I12R2_HUMAN
    • IL-12 receptor subunit beta-2
    • IL-12R subunit beta-2
    • IL-12R-beta-2
    • IL-12RB2
    • IL12 receptor beta 2
    • IL12R beta2
    • IL12RB2
    • Interleukin 12 receptor beta 2
    • Interleukin 12 receptor beta 2 chain
    • Interleukin-12 receptor subunit beta-2
    • RP11 102M16.1
    see all
  • 功能Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
  • 组织特异性Isoform 2 is expressed at similar levels in both naive and activated T-cells.
  • 序列相似性Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 5 fibronectin type-III domains.
  • 发展阶段Maximum levels in Th1 cells between day 3 and day 8 of activation.
  • 结构域The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • 翻译后修饰On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.
  • 细胞定位Membrane.
  • Information by UniProt

Recombinant Human IL12RB2 protein 图像

  • 12.5% SDS-PAGE showing ab116889 at approximately 37.73kDa stained with Coomassie Blue.

Recombinant Human IL12RB2 protein (ab116889)参考文献

ab116889 has not yet been referenced specifically in any publications.

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