The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
内毒素水平< 0.100 Eu/µg
补充说明The ED50, determined by the dose-dependent stimulation of murine D10S cells, is < 0.001 ng/ml, corresponding to a specific activity of > 1 x 109 units/mg.
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
IL 1 alpha
Interleukin 1 alpha
Preinterleukin 1 alpha
Pro interleukin 1 alpha
功能Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
序列相似性Belongs to the IL-1 family.
结构域The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
细胞定位Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.