This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitute in sterile 18Mohm/cm H2O at not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
IL 1 alpha
Interleukin 1 alpha
Preinterleukin 1 alpha
Pro interleukin 1 alpha
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Belongs to the IL-1 family.
The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.
Secreted. The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.