Recombinant人IKB beta protein (ab123184)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHH SSGLVPRGSH MGSHMAGVAC LGKAADADEW CDSGLGSLGP DAAAPGGPGL GAELGPGLSW APLVFGYVTE DGDTALHLAV IHQHEPFLDF LLGFSAGTEY MDLQNDLGQT ALHLAAILGE TSTVEKLYAA GAGLCVAERR GHTALHLACR VGAHACARAL LQPRPRRPRE APDTYLAQGP DRTPDTNHTP VALYPDSDLE KEEEESEEDW KLQLEAENYE GHTPLHVAVI HKDVEMVRLL RDAGADLDKP EPTCGRSPLH LAVEAQAADV LELLLRAGAN PAARMYGGRT PLGSAMLRPN PILARLLRAH GAPEPEGEDE KSGPCSSSSD SDSGDEGDEY DDIVVHSSRS QTRLPPTPAS KPLPDDPRPV
    • 分子量
      40 kDa including tags
    • 氨基酸
      1 to 356
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab123184 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度
    > 90 % SDS-PAGE.
    ab123184 is purified using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol

常规信息

  • 别名
    • I kappa B beta
    • I-kappa-B-beta
    • IkappaBbeta
    • IKB beta
    • IkB-B
    • IkB-beta
    • IKBB
    • IKBB_HUMAN
    • IkBbeta
    • NF kappa BIB
    • NF-kappa-B inhibitor beta
    • NF-kappa-BIB
    • Nfkbib
    • Thyroid receptor interacting protein 9
    • Thyroid receptor-interacting protein 9
    • TR interacting protein 9
    • TR-interacting protein 9
    • TRIP-9
    • TRIP9
    see all
  • 功能
    Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
  • 组织特异性
    Expressed in all tissues examined.
  • 序列相似性
    Belongs to the NF-kappa-B inhibitor family.
    Contains 6 ANK repeats.
  • 翻译后修饰
    Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
  • 细胞定位
    Cytoplasm. Nucleus.
  • Information by UniProt

图片

  • 15% SDS-PAGE showing ab123184 at approximately 40.3kDa (3µg).
    (Molecular size on SDS-PAGE will appear higher).

文献

ab123184 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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