Recombinant人IGFBP3 protein (ab88368)

概述

描述

  • 性质
    Recombinant
  • 来源
    HEK 293 cells
  • 氨基酸序列
    • 种属
      Human
    • 序列
      GASSGGLGPVVRCEPCDARALAQCAPPPAVCAELVREPGCGCCLTC AL SEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCVNASA VSRL RAYLLPAPPAPGNASESEEDRSAGSVESPSVSSTHRVSDPKF HPLHSK IIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYG PCRREMED TLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGR KRGFCWCVDK YGQPLPGYTTKGKEDVHCYSMQSK

技术指标

Our Abpromise guarantee covers the use of ab88368 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Functional Studies

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.

  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Trehalose, 1% Human serum albumin

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 复溶
    It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.

常规信息

  • 别名
    • Acid stable subunit of the 140 K IGF complex
    • Binding protein 29
    • Binding protein 53
    • BP 53
    • BP53
    • Growth hormone dependent binding protein
    • IBP 3
    • IBP-3
    • IBP3
    • IBP3_HUMAN
    • IGF binding protein 3
    • IGF-binding protein 3
    • IGFBP 3
    • IGFBP-3
    • IGFBP3
    • Insulin Like Growth Factor Binding Protein 3
    • Insulin-like growth factor binding protein 3 precursor
    • Insulin-like growth factor-binding protein 3
    see all
  • 功能
    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
  • 组织特异性
    Expressed by most tissues. Present in plasma.
  • 序列相似性
    Contains 1 IGFBP N-terminal domain.
    Contains 1 thyroglobulin type-1 domain.
  • 发展阶段
    IGFBP3 levels are higher during extrauterine life and peak during puberty.
  • 结构域
    The thyroglobulin type-1 domain mediates interaction with HN.
  • 翻译后修饰
    Phosphorylation sites are present in the extracelllular medium.
  • 细胞定位
    Secreted.
  • Information by UniProt

Recombinant human IGFBP3 protein 图像

  • Densitometry of protein isoforms visualised by 2-DE.
    The densitometry scan demonstrates the purified human cell expressed protein exists in multiple isoforms, which differ according to their level of post-translational modification.
    The triangle indicates the theoretical MWt and pI of the protein.

Recombinant human IGFBP3 protein (ab88368)参考文献

ab88368 has not yet been referenced specifically in any publications.

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