The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Biological Activity : The ED50, as determined by its ability to inhibit IGF-I induced proliferation of MCF-7, is < 0.5 µg/ml in the presence of 6 ng/ml of human IGF-I.
< 0.100 Eu/µg
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Shipped at 4°C. The lyophilized protein is stable for a few weeks at room temperature. Store at -20°C long term.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconsitute to 1mg/ml with sterile water.
Alpha pregnancy associated endometrial globulin
Amniotic fluid binding protein
Binding protein 25
Binding protein 26
Binding protein 28
Growth hormone independent binding protein
IGF binding protein 1
IGF-binding protein 1
Insulin like growth factor binding protein 1
Insulin-like growth factor-binding protein 1
Placental protein 12
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.