重组人IFN gamma Receptor beta蛋白(ab152472)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MRPTLLWSLLLLLGVFAAAAAAPPDPLSQLPAPQHPKIRLYNAEQVLSWE PVALSNSTRPVVYQVQFKYTDSKWFTADIMSIGVNCTQITATECDFTAAS PSAGFPMDFNVTLRLRAELGALHSAWVTMPWFQHYRNVTVGPPENIEVTP GEGSLIIRFSSPFDIADTSTAFFCYYVHYWEKGGIQQVKGPFRSNSISLD NLKPSRVYCLQVQAQLLWNKSNIFRVGHLSNISCYETMADASTELQQVIL ISVGTFSLLSVLAGACFFLVLKYRGLIKYWFHTPPSIPLQIEEYLKDPTQ PILEALDKDSSPKDDVWDSVSIISFPEKEQEDVLQTL
    • 分子量
      63 kDa including tags
    • 氨基酸
      1 to 337

技术指标

Our Abpromise guarantee covers the use of ab152472 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • AF 1
    • AF-1
    • AF1
    • IFGR 2
    • IFGR2
    • IFN-gamma receptor 2
    • IFN-gamma-R2
    • IFNGR 2
    • IFNGR2
    • IFNGT 1
    • IFNGT1
    • IMD28
    • INGR2_HUMAN
    • Interferon gamma receptor 2
    • Interferon gamma receptor 2 (interferon gamma transducer 1)
    • Interferon gamma receptor accessory factor 1
    • Interferon gamma receptor beta chain
    • Interferon gamma receptor chain 2
    • Interferon gamma transducer 1
    see all
  • 功能
    Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2.
  • 疾病相关
    Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
  • 序列相似性
    Belongs to the type II cytokine receptor family.
    Contains 2 fibronectin type-III domains.
  • 细胞定位
    Membrane.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab152472 stained with Coomassie Blue.

文献

ab152472 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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