Recombinant人ICAM1 protein (ab82125)

概述

描述

  • 性质
    Recombinant
  • 来源
    CHO cells
  • 氨基酸序列
    • 种属
      Human
    • 序列
      QTSVSPSKV ILPRGGSVLV TCSTSCDQPK LLGIETPLPK KELLLPGNNR KVYELSNVQE DSQPMCYSNC PDGQSTAKTF LTVYWTPERV ELAPLPSWQP VGKNLTLRCQ VEGGAPRANL TVVLLRGEKE LKREPAVGEP AEVTTTVLVR RDHHGANFSC RTELDLRPQG LELFENTSAP YQLQTFVLPA TPPQLVSPRV LEVDTQGTVV CSLDGLFPVS EAQVHLALGD QRLNPTVTYG NDSFSAKASV SVTAEDEGTQ RLTCAVILGN QSQETLQTVT IYSFPAPNVI LTKPEVSEGT EVTVKCEAHP RAKVTLNGVP AQPLGPRAQL LLKATPEDNG RSFSCSATLE VAGQLIHKNQ TRELRVLYGP RLDERDCPGN WTWPENSQQT PMCQAWGNPL PELKCLKDGT FPLPIGESVT VTRDLEGTYL CRARSTQGEV TRKVTVNVLS PRYE
    • 氨基酸
      28 to 480

技术指标

Our Abpromise guarantee covers the use of ab82125 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    ab82125 supported the adhesion of more than 50% PMA-stimulated HSB2 cells to plates coated at 25µg/ml ICAM1 concentration
  • 应用

    SDS-PAGE

    Functional Studies

  • 内毒素水平
    < 0.100 Eu/µg
  • 纯度
    > 95 % SDS-PAGE.
    Purity is greater than 98% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Antigen identified by monoclonal antibody BB2
    • BB 2
    • BB2
    • CD 54
    • CD_antigen=CD54
    • CD54
    • Cell surface glycoprotein P3.58
    • Human rhinovirus receptor
    • ICAM 1
    • ICAM-1
    • ICAM1
    • ICAM1_HUMAN
    • Intercellular adhesion molecule 1
    • intercellular adhesion molecule 1 (CD54), human rhinovirus receptor
    • Major group rhinovirus receptor
    • MALA 2
    • MALA2
    • MyD 10
    • MyD10
    • P3.58
    • Surface antigen of activated B cells, BB2
    see all
  • 功能
    ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
  • 序列相似性
    Belongs to the immunoglobulin superfamily. ICAM family.
    Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
  • 翻译后修饰
    Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
  • 细胞定位
    Membrane.
  • Information by UniProt

图片

  • Standard curve for ICAM1 (Analyte: ab82125); dilution range 1pg/ml to 1µg/ml using Capture Antibody ab2213 at 5µg/ml and Detector Antibody ab7815 at 0.5µg/ml.

文献

ab82125 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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