Recombinant人HYAL1 protein (ab112305)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ12794
    • 种属Human
    • 序列ANPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLART FQDILAAIPAPDFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQH
    • 分子量37 kDa including tags
    • 氨基酸60 to 159
    • 标签GST tag N-Terminus

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技术指标

Our Abpromise guarantee covers the use of ab112305 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性useful for Antibody Production and Protein Array
  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Best use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

常规信息

  • 别名
    • HYAL 1
    • Hyal-1
    • HYAL1
    • HYAL1_HUMAN
    • Hyaluronidase 1
    • Hyaluronidase-1
    • Hyaluronoglucosaminidase 1
    • Hyaluronoglucosaminidase-1
    • Hyaluronoglucosaminidase1
    • LUCA 1
    • LUCA-1
    • LUCA1
    • Lung carcinoma protein 1
    • MGC45987
    • NAT6
    • Plasma hyaluronidase
    • Tumor suppressor LUCA 1
    see all
  • 功能May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.
  • 组织特异性Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.
  • 疾病相关Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9) [MIM:601492]; also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement.
  • 序列相似性Belongs to the glycosyl hydrolase 56 family.
    Contains 1 EGF-like domain.
  • 细胞定位Secreted. Lysosome.
  • Information by UniProt

Recombinant Human HYAL1 protein 图像

  • ab112305 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human HYAL1 protein (ab112305)参考文献

ab112305 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"