重组人HuR / ELAVL1蛋白(ab152360)

概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MSNGYEDHMAEDCRGDIGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAK LIRDKVAGHSLGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSS EVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVA FIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQNKNVALLSQLY HSPARRFGGPVHHQAQRFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYN LGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAM AIASLNGYRLGDKILQVSFKTNKSHK
    • 分子量
      63 kDa including tags
    • 氨基酸
      1 to 362
    • 标签
      GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab152360 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

    SDS-PAGE

  • 纯度
    < 80 % SDS-PAGE.

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • ELAV (embryonic lethal abnormal vision Drosophila) like 1
    • ELAV (embryonic lethal, abnormal vision, Drosophila) like 1 (Hu antigen R)
    • ELAV like 1
    • ELAV like RNA binding protein 1
    • ELAV-like protein 1
    • ELAV1
    • ELAV1_HUMAN
    • Elavl1
    • Embryonic lethal abnormal vision drosophila homolog like 1
    • Hu Antigen R
    • Hu-antigen R
    • Hua
    • HuR
    • MelG
    see all
  • 功能
    Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs.
  • 组织特异性
    Ubiquitous.
  • 序列相似性
    Belongs to the RRM elav family.
    Contains 3 RRM (RNA recognition motif) domains.
  • 翻译后修饰
    Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab152360 stained with Coomassie Blue.

文献

ab152360 has not yet been referenced specifically in any publications.

客户评价及客户问答

The image on the datasheet is a SDS PAGE image rather than a western blot, so the amount of protein loaded for that particular gel is not necessarily applicable to your western blot. For purified protein such as ab152360 we recommend loading 10 - 100 n...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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