Recombinant人Huntingtin Interacting Protein HIP1 (ab116725)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionO00291
    • 种属Human
    • 序列DSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIK RQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPP TLQEVVTEKE
    • 分子量38 kDa including tags
    • 氨基酸928 to 1037

技术指标

Our Abpromise guarantee covers the use of ab116725 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • 2610109B09Rik
    • A930014B11Rik
    • E130315I21Rik
    • HIP 1
    • HIP I
    • HIP-1
    • HIP-I
    • hip1
    • HIP1/PDGFRB fusion gene
    • HIP1/PDGFRB fusion gene, included
    • HIP1_HUMAN
    • HIPI
    • Huntingtin interacting protein 1
    • Huntingtin-interacting protein 1
    • Huntingtin-interacting protein I
    • ILWEQ
    • KIAA4113
    • MGC126506
    • MGC27616
    • mKIAA4113
    see all
  • 功能Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
  • 组织特异性Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
  • 疾病相关Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed.
  • 序列相似性Belongs to the SLA2 family.
    Contains 1 ENTH (epsin N-terminal homology) domain.
    Contains 1 I/LWEQ domain.
  • 结构域The pseudo DED region (pDED) mediates the interaction with IFT57.
    Binds F-actin via the talin-like I/LWEQ domain.
  • 细胞定位Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle > clathrin-coated vesicle membrane. Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
  • Information by UniProt

Recombinant Human Huntingtin Interacting Protein HIP1 图像

  • 12.5% SDS-PAGE showing ab116725 at approximately 37.73kDa.
    Stained with Coomassie Blue.

Recombinant Human Huntingtin Interacting Protein HIP1 (ab116725)参考文献

ab116725 has not yet been referenced specifically in any publications.

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