Recombinant人Hsp60 protein (ab113177)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP10809
    • 种属Human
    • 分子量61 kDa
    • 氨基酸1 to 573

技术指标

Our Abpromise guarantee covers the use of ab113177 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    Functional Studies

    SDS-PAGE

  • 内毒素水平< 50.000 Eu/mg
  • 纯度> 90 % SDS-PAGE.
    ab113177 was purified by multi-step chromatography.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: 0.09% Sodium azide
    Constituents: 99% PBS, Phosphate Buffer

常规信息

  • 别名
    • 60 kDa chaperonin
    • 60 kDa heat shock protein, mitochondrial
    • CH60_HUMAN
    • Chaperonin 60
    • Chaperonin, 60-KD
    • CPN60
    • fa04a05
    • GROEL
    • heat shock 60kDa protein 1 (chaperonin)
    • Heat shock protein 1 (chaperonin)
    • Heat shock protein 60
    • Heat shock protein 65
    • heat shock protein family D (Hsp60) member 1
    • HLD4
    • Hsp 60
    • HSP 65
    • HSP-60
    • HSP60
    • HSP65
    • HSPD1
    • HuCHA60
    • Mitochondrial matrix protein P1
    • P60 lymphocyte protein
    • short heat shock protein 60 Hsp60s1
    • SPG13
    see all
  • 功能Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
  • 疾病相关Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13) [MIM:605280]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
    Defects in HSPD1 are the cause of leukodystrophy hypomyelinating type 4 (HLD4) [MIM:612233]; also called mitochondrial HSP60 chaperonopathy or MitCHAP-60 disease. HLD4 is a severe autosomal recessive hypomyelinating leukodystrophy. Clinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurrs within the first two decades of life.
  • 序列相似性Belongs to the chaperonin (HSP60) family.
  • 细胞定位Mitochondrion matrix.
  • Information by UniProt

Recombinant Human Hsp60 protein 图像

  • SDS-PAGE analysis of ab113177: Lane 1: MW marker, Lane 2: 0.5ug, Lane 3: 1ug, Lane 4: 2.5ug, Lane 5: 5ug, Lane 6: 10ug.
  • All lanes : a monoclonal anti Hsp60 protein

    Lane 1 : molecualr weight marker
    Lane 2 : Recombinant Human Hsp60 protein (ab113177) at 0.1 µg
    Lane 3 : Recombinant Human Hsp60 protein (ab113177) at 0.05 µg

Recombinant Human Hsp60 protein (ab113177)参考文献

ab113177 has not yet been referenced specifically in any publications.

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