Recombinant人HRG beta 1 protein (ab55742)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • 种属
      Human
    • 序列
      SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQ NYVM ASFYKHLGIE FMEAE

技术指标

Our Abpromise guarantee covers the use of ab55742 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Functional Studies

  • 纯度
    > 98 % SDS-PAGE.
    purification checked by SDS Page and HPLC.
  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Endotoxin level: < 0.1 ng per µg of HRG beta-1

  • 复溶
    Reconstitute in water to a concentration of 0.1-1.0 mg/ml.

常规信息

  • 别名
    • Acetylcholine receptor inducing activity
    • ARIA
    • Breast cancer cell differentiation factor p45
    • GGF
    • GGF2
    • glial growth factor
    • Heregulin
    • Heregulin beta1
    • heregulin, alpha (45kD, ERBB2 p185 activator)
    • HGL
    • HRG
    • HRG beta 1A
    • HRG1
    • HRGA
    • NDF
    • neu differentiation factor
    • Neuregulin 1
    • NRG1
    • sensory and motor neuron derived factor
    • SMDF
    see all
  • 相关性
    HRG beta 1 is an isoform from the Neuregulin/Heregulin family of structurally related polypeptide growth factors which are derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. HRG1-ß1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. Although HRG1-ß1 biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility promoting factor (AMF).
  • 细胞定位
    Secreted

Recombinant Human HRG beta 1 protein (ab55742)参考文献

ab55742 has not yet been referenced specifically in any publications.

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