Recombinant人HPRT protein (ab117153)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP00492
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MATRSPGVVI SDDEPGYDLD LFCIPNHYAE DLERVFIPHG LIMDRTERLA RDVMKEMGGH HIVALCVLKG GYKFFADLLD YIKALNRNSD RSIPMTVDFI RLKSYCNDQS TGDIKVIGGD DLSTLTGKNV LIVEDIIDTG KTMQTLLSLV RQYNPKMVKV ASLLVKRTPR SVGYKPDFVG FEIPDKFVVG YALDYNEYFR DLNHVCVISE TGKAKYKA
    • 分子量27 kDa including tags
    • 氨基酸1 to 218
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab117153 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab117153 was purified by proprietary chromatographic techniques and filter sterilized.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 20% Glycerol

常规信息

  • 别名
    • HGPRT
    • HGPRTase
    • HPRT 1
    • HPRT_HUMAN
    • HPRT1
    • Hypoxanthine guanine phosphoribosyltransferase
    • Hypoxanthine phosphoribosyltransferase 1
    • Hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome)
    • Hypoxanthine-guanine phosphoribosyltransferase
    see all
  • 功能Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
  • 通路Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.
  • 疾病相关Defects in HPRT1 are the cause of Lesch-Nyhan syndrome (LNS) [MIM:300322]. LNS is characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation.
    Defects in HPRT1 are the cause of gout HPRT-related (GOUT-HPRT) [MIM:300323]; also known as HPRT-related gout or Kelley-Seegmiller syndrome. Gout is characterized by partial enzyme activity and hyperuricemia.
  • 序列相似性Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  • 细胞定位Cytoplasm.
  • Information by UniProt

Recombinant Human HPRT protein (ab117153)参考文献

ab117153 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab117153.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"