Recombinant人hPDE4D2 protein (ab80335)

概述

  • 产品名称Recombinant人hPDE4D2 protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab80335 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Specific Activity: 36365 pmol/min/µg.
  • 应用

    SDS-PAGE

    Functional Studies

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • 9630011N22Rik
    • cAMP specific 3' 5' cyclic phosphodiesterase 4D
    • cAMP specific phosphodiesterase 4D
    • cAMP specific phosphodiesterase PDE4D
    • cyclic AMP phosphodiesterase
    • DPDE3
    • Dunce like phosphodiesterase E3
    • HSPDE4D
    • PDE4D
    • PDE4DN2
    • Phosphodiesterase 4D cAMP specific
    • Phosphodiesterase E3 dunce homolog Drosophila
    • STRK 1
    • STRK1
    see all
  • 相关性Cyclic AMP-dependent phosphodiesterase type D (PDE4D) family is comprised of 5 variants (PDE4D1, D2, D3, D4 and D5). One or more PDE4D subtype variants are ubiquitously present in all mammalian cells. In CNS all five PDE4D subtype variants are expressed in varying ratios and their activity is regulated in tandem with GPCRs stimulation. Peripheral tissues also exhibit differential expression of PDE4D variants. PDE4D1/D2 mRNA levels rise in response to an increase in cAMP. Short term regulation of PDE4D variants involved PKA, MAP kinases and Erk2 phosphorylation that results in rapid change in their enzymatic activities. Other regulatory mechanism involved protein protein interactions with cytoskeletal scaffolding proteins.
  • 细胞定位Cytoplasm. Membrane. Cytoplasm; cytoskeleton. Centrosome. Note= Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome

Recombinant human hPDE4D2 protein 图像

  • 10% SDS-PAGE showing ab80335 at approximately 103kDa (4µg).

Recombinant human hPDE4D2 protein (ab80335)参考文献

ab80335 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"