Recombinant人HP1 gamma protein (ab88011)

概述

描述

  • 性质Recombinant
  • 来源Saccharomyces cerevisiae
  • 氨基酸序列
    • 种属Human
    • 序列MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKV EYF LKWKGFTDADNTWEPEENLDCPELIEAFLNSQKAGKEKDGTK RKSLSD SESDDSKSKKKRDAADKPRGFARGLDPERIIGATDSSGE LMFLMKWKD SDEADLVLAKEANMKCPQIVIAFYEERLTWHSCPED EAQ

技术指标

Our Abpromise guarantee covers the use of ab88011 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

  • 纯度> 90 % SDS-PAGE.
    Purified by affinity chromatography.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 0.5% Triton-X-100, 50mM HEPES, 30mM Glutathione, 100mM Sodium chloride, 1mM DTT, pH 7.5

常规信息

  • 别名
    • CBX 3
    • CBX3
    • CBX3_HUMAN
    • Chromobox homolog 3
    • Chromobox homolog 3 (HP1 gamma homolog, Drosophila)
    • Chromobox protein homolog 3
    • GAMMA
    • HECH
    • Heterochromatin like protein 1
    • Heterochromatin protein 1 homolog gamma
    • Heterochromatin protein HP1 gamma
    • HP1 gamma
    • HP1 gamma homolog
    • HP1Hs gamma
    • Modifier 2 protein
    see all
  • 功能Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
  • 序列相似性Contains 2 chromo domains.
  • 翻译后修饰Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
  • 细胞定位Nucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis.
  • Information by UniProt

Recombinant Human HP1 gamma protein (ab88011)参考文献

ab88011 has not yet been referenced specifically in any publications.

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