Recombinant人HP1 gamma protein (ab124548)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHH SSGLVPRGSH MGSHMASNKT TLQKMGKKQN GKSKKVEEAE PEEFVVEKVL DRRVVNGKVE YFLKWKGFTD ADNTWEPEEN LDCPELIEAF LNSQKAGKEK DGTKRKSLSD SESDDSKSKK KRDAADKPRG FARGLDPERI IGATDSSGEL MFLMKWKDSD EADLVLAKEA NMKCPQIVIA FYEERLTWHS CPEDEAQ
    • 分子量
      23 kDa including tags
    • 氨基酸
      1 to 183
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab124548 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度
    > 90 % SDS-PAGE.
    Purified by using conventional chromatography.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 20% Glycerol, 0.58% Sodium chloride

常规信息

  • 别名
    • CBX 3
    • CBX3
    • CBX3_HUMAN
    • Chromobox homolog 3
    • Chromobox homolog 3 (HP1 gamma homolog, Drosophila)
    • Chromobox protein homolog 3
    • GAMMA
    • HECH
    • Heterochromatin like protein 1
    • Heterochromatin protein 1 homolog gamma
    • Heterochromatin protein HP1 gamma
    • HP1 gamma
    • HP1 gamma homolog
    • HP1Hs gamma
    • Modifier 2 protein
    see all
  • 功能
    Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
  • 序列相似性
    Contains 2 chromo domains.
  • 翻译后修饰
    Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
  • 细胞定位
    Nucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis.
  • Information by UniProt

图片

  • 15% SDS-PAGE (3 µg loaded)

文献

ab124548 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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