Recombinant人HP1 alpha protein (ab124602)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP45973
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MGSHMGKKTK RTADSSSSED EEEYVVEKVL DRRVVKGQVE YLLKWKGFSE EHNTWEPEKN LDCPELISEF MKKYKKMKEG ENNKPREKSE SNKRKSNFSN SADDIKSKKK REQSNDIARG FERGLEPEKI IGATDSCGDL MFLMKWKDTD EADLVLAKEA NVKCPQIVIA FYEERLTWHA YPEDAENKEK ETAKS
    • 分子量25 kDa including tags
    • 氨基酸1 to 191
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab124602 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab124602 is purified by using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.02% DTT, 0.32% Tris HCl, 30% Glycerol, 0.58% Sodium chloride

常规信息

  • 别名
    • Antigen p25
    • CBX5
    • CBX5_HUMAN
    • CG8409
    • Chromobox 5
    • Chromobox homolog 5
    • Chromobox homolog 5 (HP1 alpha homolog, Drosophila)
    • Chromobox protein homolog 5
    • Epididymis luminal protein 25
    • HEL25
    • Heterochromatin protein 1
    • Heterochromatin protein 1 alpha
    • Heterochromatin protein 1 homolog alpha
    • HP1
    • HP1 alpha
    • HP1 alpha homolog
    • HP1A
    • HP1Hs alpha
    • Su(var)205
    see all
  • 功能Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
  • 序列相似性Contains 2 chromo domains.
  • 翻译后修饰Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
    Ubiquitinated.
  • 细胞定位Nucleus. Chromosome. Chromosome > centromere. Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.
  • Information by UniProt

Recombinant Human HP1 alpha protein 图像

  • 15% SDS-PAGE showing ab124602 (3 µg).

Recombinant Human HP1 alpha protein (ab124602)参考文献

ab124602 has not yet been referenced specifically in any publications.

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