Recombinant人HOPX protein (ab125982)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9BPY8
    • 种属Human
    • 分子量8 kDa
    • 氨基酸1 to 73
    • 标签His-DHFR tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab125982 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20ºC.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 复溶Reconstitute with water to desired concentration.

常规信息

  • 别名
    • CAMEO
    • heart odd homeobox 1 protein
    • HOD
    • Homeodomain-only protein
    • HOP
    • HOP homeobox
    • HOP_HUMAN
    • HOPX
    • LAGY
    • Lung cancer-associated Y protein
    • NECC1
    • Not expressed in choriocarcinoma clone 1
    • Not expressed in choriocarcinoma protein 1
    • OB1
    • odd homeobox 1 protein
    • Odd homeobox protein 1
    • OTTHUMP00000158970
    • SMAP31
    • TOTO
    see all
  • 功能Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.
  • 组织特异性Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma.
  • 序列相似性Contains 1 homeobox DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human HOPX protein (ab125982)参考文献

ab125982 has not yet been referenced specifically in any publications.

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